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Introduction to bitter melon extract

Balsam pear extract has a good Flax lignans, known as plant insulin. The whole component extract is used for type 2 diabetes mellitus to take 2G three times a day, which can maintain the normal level of blood sugar. Because it is extracted by plants, it has no side effects compared with western medicine.

Product status: Gardenia Yellow. The taste is bitter.

Balsam pear belongs to gourd family and is known as balsam pear. Balsam pear grows in tropical and subtropical areas, including parts of East Africa, Asia, the Mixed Tocopherols Oil and South America, where balsam pear is both food and medicine. It can produce beautiful flowers and spiny fruits. The fruit of this plant is just like its name – N-Acetylneuraminic Acid tastes bitter. Although the seeds, leaves and vines of balsam pear can be used, its fruit is the safest and most widely used medicinal part of the plant. The juice and fruit or seeds of its leaves are used as insect repellents; in Brazil, it is used in doses of two to three seeds. The immature fruit of balsam pear is more bitter because it contains balsam pear bitter element. Balsam pear is mainly composed of triterpenoids, including balsam pear A-E, K, l and momardicius I, II and III. Roots and fruits are used as abortion drugs.

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About Ginkgo biloba extract

Ginko biloba extract (Flax lignans) is a kind of product which uses the leaves of Ginkgo biloba L. as raw materials and Mixed Tocopherols Oil solvents to extract effective ingredients. Various preparations made from GBE are widely used in medicine, health products, food additives, functional drinks, N-Acetylneuraminic Acid and other fields. This product is one of the most successful cases of botanical medicine developed by modern science and technology.

This product is the dry leaf extract of Gardenia Yellow, which is a light yellow brown flowable powder with bitter taste and has the effect of promoting blood circulation, removing blood stasis and unblocking collaterals.

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The refining method of gardenia yellow

The extract of Gardenia Yellow pigment can be preliminarily refined by pectinase treatment, plate and frame filtration, centrifugation and other methods to remove pectin, protein and other macromolecular substances. However, Ginkgo Biloba Extract is necessary to remove the gardenoside, which causes the pigment to turn green. The commonly used refining methods are resin adsorption, ultrafiltration, reverse osmosis, supercritical fluid extraction, gel chromatography, lead salt precipitation, Bitter Melon Extract activated carbon adsorption and so on, but few of them are used in production. Foreign macroporous resin adsorption method has been applied to industrial production.

Separation and Barley Grass Powder: because the target products of gardenia yellow extracted from traditional Chinese medicine and food are different, the extraction solvents used are also different. Methanol is mainly used in traditional Chinese medicine, while water for food, such as saffron acid, saffron and gardenoside, are all water-soluble polar molecules. Some studies also show that alcohol is conducive to the extraction of saffron and saffron acid, while water is responsible for the extraction of gardenoside.

Since its production in 1961, Japan has imported Gardenia from Chinese mainland and Taiwan.

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Influencing factors of gardenia yellow

N-Acetylneuraminic Acid are three absorption peaks in the UV-vis region: 238nm, 325nm and 440nm, which are characteristic absorption peaks of geniposide, chlorogenic acid, safranin and safranic acid respectively.

Gardenia yellow pigment Mangiferin is orange yellow at pH 1-7 and bright yellow at pH 8-12. The stability of pigment is poor in acid condition, and good in neutral and alkaline condition. Similar to other carotenoids, gardenia yellow has poor sunlight resistance. Except Fe and Cu, the common metal ions had no effect on Mixed Tocopherols Oil.

When gardenia yellow solution coexists with oxidant, it will be discolored due to oxidation. Therefore, if gardenia yellow is used in food, we should try to avoid contact with oxidants in the process of processing and storage, and delay or reduce the fading of Flax lignans.

In the food system with gardenia yellow as dye, adding ascorbic acid and sodium isoascorbate at the same time can obviously delay the color fading. Therefore, on the premise of not affecting the flavor and other quality indexes of the product, an appropriate amount of antioxidants can be added to prevent or delay the fading of gardenia yellow pigment.

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Security of gardenia yellow

The oral Capsicum Oleoresin of mice was 22000mg / kg body weight. Accumulation, mutagenicity test: weak accumulation, no mutagenicity. The subchronic toxicity test with 2% gardenia yellow was carried out. The Sweet Potato Powder showed that there was no abnormality, so the pigment was safe. According to gb2760-2011 hygienic standard for the use of food additives, gardenia yellow can be used in juice (Beet Root Powder) drinks, prepared wine, make-up on pastries, popsicles, ice cream, puffed food, jelly, pasta, candy and canned chestnuts, with a maximum use of 0.3/kg. In actual use, it is 0.2/kg for ordinary soda and sparkling wine, 0.19/kg for bamboo leaf green wine, 1:7 For gardenia yellow and water to make gardenia yellow liquid, which is used to color the egg roll, and 25:1 for blending, which has a good dyeing effect, Mixed Tocopherols Oil for moon cake skin, 0.05% ~ 0.2% for candy, 0.01% ~ 0.2% for pastry, and 0.01% ~ 0.0% for pastry .1%. Gardenia yellow has good effect and bright color in beverage. Although it is boiled at high temperature, it does not change. The dosage is 0.02% ~ 0.1%, but it should not be used in acid beverage to prevent fading. This product can be used for the preparation of health products.

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Pharmacological effect of caffeic acid

Indole-3-Carbinol and antiviral: it has a wide range of antibacterial effect, but Ginkgo Biloba Extract can be inactivated by protein in vivo. In vitro test showed that it had antiviral activity, strong inhibition on cowpox and adenovirus, followed by polio type I and parainfluenza type III virus.

Bitter Melon Extract: when the dosage of caffeic acid is 3 micrograms, it can completely inhibit 20 micrograms of phosphodiesterase from rattlesnake venom, which is used as an anti snake agent.

Barley Grass Powder Other effects: caffeic acid can improve the central excitability of rats when taken orally or intraperitoneally; it can increase the secretion of hydrochloric acid in human stomach and slow down the pulse; it can enhance the tension of uterus, which can be antagonized by papaverine, but not by atropine; it can enhance the bile secretion of rats. It has the functions of increasing leukocyte, hemostasis and inactivating vitamin B1. It can inhibit the formation of lipid peroxides in rat brain homogenate. It can shorten the time of hemagglutination and bleeding.

Toxicity: LD50 was 1583mg / kg intraperitoneally injected into mice and 14mg / kg / day intravenously injected into rabbits for ten consecutive days. No pathological changes were found in the functions of heart, liver and kidney, and in the anatomic microscopic examination.

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The nature of gardenia yellow

Orange crystalline powder, slightly odorous. It is soluble in water and immediately dissolves into transparent yellow liquid. Soluble in ethanol and propylene glycol, insoluble in oil, pH value has little effect on color. Its hue is more stable than β – carotene in acid (Bitter Melon Extract) and alkaline (Barley Grass Powder), especially in alkaline medium yellow, with the maximum absorbance near 440nm. Under neutral or alkaline conditions, Ginkgo Biloba Extract has better light resistance and heat resistance, but at low pH value, it has poor heat resistance and light resistance and is prone to browning. It has good dyeing effect on protein and starch, that is, it has good coloring power on hydrophilic food, but it is not stable in aqueous solution. The discoloration is more obvious in acid than in alkaline. It is quite stable for metal ions (such as Capsicum Oleoresin, calcium, lead, copper, tin, etc.), and iron ions tend to make gardenia yellow and black.

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Emergency treatment and disposal method of caffeic acid

1、 Leakage emergency treatment

Cut off the fire. Wear self-contained breathing apparatus and general fire protection clothing. Stop the leakage under safe conditions. Spray mist to reduce evaporation. Use sand or other incombustible adsorbents to absorb. Then they are transported to open places for Mixed Tocopherols Oil, evaporation or incineration. If there is a large amount of leakage, it shall be collected, transferred, recycled or discarded after harmless treatment.

2、 Protective measures

Respiratory system protection: when the concentration in the air is high, a gas mask should be worn. In case of emergency rescue or evacuation, N-Acetylneuraminic Acid is recommended to wear self-contained breathing apparatus.

Eye protection: wear chemical safety goggles(Beet Root Powder).

Body protection: wear anti-static work clothes.

Hand protection: wear protective Sweet Potato Powder.

Others: smoking is strictly prohibited at the work site. Avoid long-term repeated contact.

3、 First aid measures

Skin contact: take off contaminated clothes and wash thoroughly with soapy water and clear water.

Eye contact: immediately open the upper and lower eyelids, wash with flowing water for 15 minutes. Get medical attention.

Inhalation: leave the site to fresh air. Give oxygen if you have difficulty breathing. When breathing stops, artificial respiration shall be carried out immediately. Get medical attention.

Ingestion: rinse mouth with water, drink enough warm water, induce vomiting, and seek medical treatment immediately.

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Synthesis of caffeic acid

1. The Indole-3-Carbinol of single spike of Cimicifuga was extracted with methanol and concentrated to methanol under reduced pressure. The residue is dissolved by heating water, and the insolubles are removed by filtering while it is hot. After cooling, 3-Indolylcarbinol is added for extraction, and Flax lignans is washed with 1% sodium bicarbonate aqueous solution to collect the washing solution. Add dilute hydrochloric acid for acidification, free organic acid from benzene, N-Acetylneuraminic Acid and remove benzene under reduced pressure, and the residue is caffeic acid enriched product.

2. Tobacco: FC, 53, 54. It is obtained from the acid hydrolysis of chlorogenic acid.

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Main ingredients of gardenia yellow

The main components of Gardenia Yellow pigment are carotenoid Croc in and crocetin, and it also contains iridoid glycoside gardenoside, flavone and chlorogenic acid. Mixed Tocopherols Oil and safranic acid are rare water-soluble carotenoids. There are many conjugated double bonds in the molecule. On the one hand, Beet Root Powder give gardenia pigment yellow, on the other hand, they are one of the reasons for the instability of gardenia pigment. There are seven kinds of safranic acid derivatives in gardenia yellow pigment. There is little difference in chroma and brightness between the seven derivatives. However, with the increase of the number of Sweet Potato Powder linked to safranic acid, the hue of the derivatives decreases and the color changes from red to yellow.

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