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Brief introduction to N-acety Lneuraminic Acid

An enzyme (N-Acetylneuraminic Acid) that hydrolyses and removes the terminal N-acetylneuraminidase is widely distributed in nature, from viruses to animals. For example, this sugar residue forms the binding site for influenza viruses that form the cell membrane of red blood cells Capsicum Oleoresin and plays a major role in the recognition of plasma glycoproteins to liver cells or lymphocyte recognition mechanisms for circulatory pathways. Although the biosynthetic pathway is somewhat different in animals and bacteria, it is catalyzed by specific pyrophosphatase and Sweet Potato Powder reaction to produce CMP-N-acetylneuraminidine, which is incorporated into the sugar chain by glycosyl transfer reaction.

Classification: Carbohydrate

N-acetylneuraminicacid is the most widely distributed sialic acid (Barley Grass Powder) in nature, which is mainly a constituent sugar of glycoproteins, glycolipids or bacterial capsules in animal cell membranes or secretions. In glycoproteins or glycolipids, it is located at the non-reductive end of the glycolipid chain due to the formation of the glucoside bond at the 2-position ketone, and its negative charge or unique chemical structure gives it various physiological specificity.

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Anti aging of Ginkgo biloba extract

antioxidant

Ginkgo Biloba Extract P.E. may play an antioxidant role in brain, eyeball, retina and cardiovascular system. Its antioxidant effect in the brain and central nervous system may help to prevent the decline of brain function due to age. The Mangiferin function of Ginkgo biloba extract in the brain is particularly interesting. The brain and central nervous system are particularly vulnerable to free radicals. Brain damage caused by free radicals is widely considered to be the influencing factor of many diseases accompanied with aging, including Alzheimer’s disease.

anti-aging

Ginkgo biloba P.E., an extract of Gardenia Yellow, can enhance cerebral blood flow and has an excellent tonic effect on nervous system. Hundreds of scientific studies involving tens of thousands of patients have confirmed the effectiveness of Ginkgo biloba extract on many problems, including cerebral blood flow insufficiency and mental retardation in elderly patients. Ginkgo biloba has good effects on many possible symptoms of aging, such as anxiety and depression, memory impairment, difficulty in focusing, decreased alertness, decreased intelligence, dizziness, headache and tinnitus (ringing in the ear), macular degeneration (the most common cause of Flax lignans in adults), inner ear agitation (which can cause partial deafness), and terminal circulatory dysfunction Impotence caused by poor blood flow of penis.

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What does Ferulic Acid do to skin

Ferulic Acid is used more as a drug and is widely used in the food industry as an antioxidant. In recent years, ferulic acid has also begun to be used in the cosmetics industry. Flax lignans in the skin care industry is mainly based on the whitening and antioxidant effects of ferulic acid:

It has been reported that ferulic acid can inhibit or reduce the proliferation activity of melanocytes. The number of melanocyte can be reduced from 117±23/mm2 to 39±7/ mm2 by using 0.1 ~ 0.5% ferulic acid solution. At the same time, N-Acetylneuraminic Acid can also inhibit the activity of tyrosinase, and the inhibition rate of ferulic acid solution with a concentration of 5mmol/L to the activity of tyrosinase is as high as 86%. Even with a concentration of 0.5mmol/L ferulic acid solution, the inhibition rate of tyrosinase activity can reach about 35%.

In addition, Sweet Potato Powder also has scavenging oxygen free radicals and good antioxidant effects. In addition, it has been reported that ferulic acid has the ability of sunscreen, and ferulic acid can effectively absorb ultraviolet radiation in the wavelength range of 290 ~ 330nm to prevent or reduce the damage caused by ultraviolet radiation at this wavelength to the skin.

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Ginkgo biloba extract against dementia

Alzheimer’s disease and memory improvement.

The scientists reviewed all published high-quality studies on Ginkgo Biloba Extract and mild memory impairment and concluded that ginkgo was significantly more effective than placebo in improving memory and perception. Ginkgo biloba is widely used in Europe to treat dementia. Capsicum Oleoresin is believed to help prevent or treat these brain disorders because it increases brain blood flow and antioxidant function. Despite the scientific flaws in many clinical trials, evidence that Gardenia Yellow may increase the ability to think, learn and remember in Alzheimer’s patients is highly expected.

Although there is no double-blind trial basis for this function, case reports and open studies suggest that Mangiferin can improve sexual dysfunction caused by promethazides and other antidepressants.

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On the security of bitter Mellon extract

High doses can cause diarrhea. Those with hypoglycemia, insulin type diabetes should avoid using balsam pear Bitter Melon Extract.

Momordica charantia has been proved to be a hypoglycemic substance. One of the reliable hypoglycemic active substances is Momordica charantia, which is a mixture of daucosterol glucoside and daucosterol glucoside. Therefore, Mangiferin is very important to measure the extract of Momordica charantia with total active components and Momordica charantia Pavilion as the standard. The standard extract of Momordica charantia has been proved to be effective for psoriasis, cancer susceptibility, pain caused by neurological complications, Gardenia Yellow and may delay the onset of cataract or retinopathy and inhibit HIV by destroying the viral DNA. Its anticancer properties are partly due to the enhancement of immune function. Studies have shown that Momordica charantia extracts inhibit lymphocyte proliferation and Flax lignans and lymphocyte activity.

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About the research progress of Flax lignans

Exist widely in plant kingdom of lignans compounds, Capsicum Oleoresin can pass the animal the microbes into animal wooden fat element in the body and has biological activity such as sample estrogen Mangiferin and anti-estrogen. A large number of studies have shown that animals wooden fat element and its precursor substances in plants has anti-cancer, oxidation resistance, resistance to diseases of the cardiovascular system and clinical application value, Sweet Potato Powder and can through the way such as and sex hormone receptors play other physiological functions, and thus has important application value in the field of animal production.

Many scholars in wooden fat element detection method, metabolic conversion, health care and physiological function were studied. Among various kinds of plant seeds, flaxseed fat content of the highest in the wood, Flax lignans is a widely cultivated cash crop in north China. The development and utilization of lignin from flaxseed will bring good economic and social benefits.

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On the theoretical support of Bitter Melon Extract

The antidiabetic effect of Momordica charantia has been confirmed by STZ induced diabetic experiment. Bitter Melon Extract can induce the increase of blood glucose accompanied by the increase of blood urea, serum creatinine, serum cholesterol and free fatty acids, as well as the decrease of liver glycogen reserve and the loss of body weight. The ground Momordica charantia seeds mixed in rabbit feed can reduce blood glucose level and blood lipid. Capsicum Oleoresin cells of the pancreas can be activated by this treatment. Alloxan can induce diabetes by destroying all B-cells in the pancreas. This suggests that the hypoglycemic activity of Momordica charantia may be mediated by some Flax lignans of these cells. This has been partially confirmed by experiments by Willy Huida and her colleagues. These researchers demonstrated that the water extract from the immature fruit of Momordica charantia is an effective stimulant to stimulate insulin release from pancreatic B-cells.

In a clinical trial designed to evaluate the effect of Momordica charantia on glucose tolerance in patients with diabetes, the Gardenia Yellow of Momordica charantia was found to significantly increase glucose tolerance in 73% of the investigated patients, while the other 27% did not respond.

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Promoting cycle of Ginkgo biloba extract

Ginkgo biloba P.E. can promote the circulation of brain and body at the same time. One of the main health functions of Ginkgo biloba P.E. is to inhibit a substance called platelet activating factor (Capsicum Oleoresin), a mediator released from cells that causes platelets to aggregate (pile up). High levels of PAF can cause nerve cell damage, decreased central nervous system blood flow, inflammation, and bronchoconstriction. Similar to free radicals, high levels of PAF also lead to aging. Gardenia Yellow and ginkgo bilobalide can protect the nerve cells of the central nervous system from injury during the period of ischemia. This function may have an adjuvant effect on patients suffering from stroke. In addition to inhibiting platelet adhesion, Mangiferin biloba extract regulates vascular tension and elasticity. In other words, it makes the circulation more efficient. The effect of improving circulation efficiency has the same effect on the large blood vessels (N-Acetylneuraminic Acid) and small blood vessels (capillaries) in the circulatory system.

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Physicochemical properties of Ginkgo biloba extract(3)

Functional group reaction

Capsicum Oleoresin often have alcohol hydroxyl, phenolic hydroxyl, methoxy, methylene dioxy, carboxyl and lactone groups, so they also have the Sweet Potato Powder and reactions of these functional groups. Ferric chloride or diazotization reagent can be used for the detection of phenolic hydroxyl group, Labat reagent (Bitter Melon Extract concentrated sulfuric acid reagent) or ecgrine reagent (chromotropic acid concentrated sulfuric acid reagent) can be used for the detection of methylene dioxy.

Neolignans

In this kind of Flax lignans, the two phenylpropanoids are usually connected by benzene ring and side chain or by oxygen bond. The γ – carbon atoms of the side chain are mostly non oxidized.

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Physicochemical properties of Ginkgo biloba extract(2)

solubility

Free Ginkgo Biloba Extract are lipophilic, generally insoluble in water, but easily soluble in lipophilic organic solvents and ethanol.

Gardenia Yellow with phenolic hydroxyl groups are also soluble in alkaline aqueous solutions. When lignans combine with sugar to form glycosides, the hydrophilicity and water solubility of lignans increase.

Optical activity

Mangiferin usually have multiple chiral carbon atoms or chiral centers, so most of them have optical activity. The physiological activity of lignans is often related to the configuration of chiral carbon. Therefore, attention should be paid to the operating conditions in the Indole-3-Carbinol extraction process to avoid structural changes of the extracted components.

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