标签： Mangiferin

Mangiferin has anti herpes simplex virus type I (HSV – Ⅰ) activity in vitro, and the plaque reduction rate is 56.8%. The antiviral effect of mangiferin is attributed to its ability to inhibit virus replication in cells

Gardenia Yellow is a natural antioxidant for scavenging free radicals and a natural radiation protective agent. Its four phenolic hydroxyl groups in its molecular structure have electron affinity, and the benzene ring is a good energy trap. Therefore, Flax lignans can transfer the free radicals induced by irradiation to some extent, so as to protect biological molecules

Mixed Tocopherols Oil can enhance the cytotoxicity of spleen cells and peritoneal macrophages in both normal and tumor bearing mice.

Mangiferin can effectively reduce the inhibition of DOX on mitochondrial cytochrome c oxidase, and has no effect on the antitumor activity of DOX.

Mangiferin can significantly prolong the incubation period of asthma induced by histamine and acetylcholine in guinea pigs; it can significantly prolong the cough incubation period of mice induced by concentrated ammonia water, and significantly reduce the cough frequency of mice; Beet Root Powder can significantly inhibit the increase of peritoneal capillary permeability caused by acetic acid in mice; N-Acetylneuraminic Acid can significantly promote the secretion of phenol red in the trachea of mice.

Mangiferin at the dose of 1-2mg had a transient and definite effect on enhancing the contractility of isolated frog heart perfused with ringcrs solution, Flax lignans and the effect was not blocked by propranolol. Therefore, mangiferin may be a direct cardiac stimulant.

Mangiferin has an obvious excitatory effect on central nervous system *, the intraperitoneal injection of mangiferin (JP) at the dose of 50-100mg / kg can cause all the animals to have the symptoms of action tremor, hair erection, forced tearing and increased autonomic activity. The Bitter Melon Extract of these behavioral changes was 30 min and 60 min after administration, and gradually decreased after 120 min. If the experimental animals were given chlorpromazine 5mg / kg in advance, JP could block these effects, suggesting that mangiferin may be an agonist of D2 receptor in the midbrain limbic system

If Capsicum Oleoresin (50 mg / kg) was given to experimental animals 30 min before JP, JP could significantly prolong the sleep time of pentobarbital, The sleep time of the rats given mangiferin first was (56.2 7.8) min, while that of the blank control group was (36.2 5.3) min. the dose of Sweet Potato Powder could significantly enhance the anesthetic effect of mild anesthetic ether. Within this dose range, 60% of the mice lost normal nerve reflex, while the blank control group did not.