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The application of Mango Leaf Extract

Modern pharmacological studies have shown that the chemical components of Mangiferin leaf extract mainly include: mangiferin, mangiferin, quercetin, gallic acid, catechol, shikimic acid, shanai acid, Indole-3-Carbinol, cyperene and volatile components. Mango leaf extract has the effect of relieving asthma, relieving cough and removing phlegm. However, no studies have been reported on the prevention and treatment of metabolic syndrome with mango leaf extract. Mango leaf extract has good curative effect in treating chronic bronchitis. It is the main effective component in treating hepatitis and the active component in rhizome of Anemone.

Modern medical studies have confirmed that Mango Leaf Extract also has anti-oxidant, anti-inflammatory, antibacterial, anti radiation, prevention and treatment of skin aging, fall blood sugar, blood uric acid, anti-tumor, immune regulation, cholagogue function, inhibiting the central nervous system, anti-inflammatory against herpes simplex virus Mixed Tocopherols Oil, alleviate the sacral nerve roots of HSV – 2 viruses cause disease many pharmacological functions, such as in China pharmacopoeia and a variety of traditional Chinese medicine, proprietary Chinese medicine quality standard, content of mangiferin is often used as quality control index. At present, the new health products or drugs developed with mango leaf extract as the main component are generally for internal use. Due to the low bioavailability of mangiferin to human body, the clinical trial results of these products are not ideal.

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Background and overview of Mango Leaf Extract(2)

In addition, Mango Leaf Extract improved hyperinsulinemia in Kk-AY mice. Based on the above results, mangiferin may show antidiabetic activity through insulin sensitization.

In the existing technology, the preparation method of Sweet Potato Powder is concentrated and dried after extraction. The content of mangiferin is low, and it belongs to the crude way with low potency. Refined method using macroporous adsorption resin or silica gel chromatography, silica gel chromatography using a large amount of organic solvent is not suitable for mass production, Gardenia Yellow macroporous adsorption resin purification way, USES a high concentration of ethanol elution, but hard to get the content of mangiferin reached more than 50% of the mango leaves extract, and, more importantly, elution of Capsicum Oleoresin can’t realize the prevention and treatment of diabetes and lipid-lowering effect.

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Background and overview of Mango Leaf Extract(1)

Mango Leaf Extract are the leaves of the sumac plant MangiferaindicaL. According to “Chinese traditional medicine big dictionary” record: mango folic acid, gan, the sex is cool. Line of air drainage, to sha product; Heat stagnation abdominal pain, flatulence; And wash the sores. Flax lignans, the main component of mango leaf extract, is an effective component in the treatment of respiratory diseases and is found in other families and plants. Modern pharmacological studies have shown that mango leaf extract has anti-asthma, cough, expectoration, immunity, anti-inflammatory and analgesic effects, anti-oxidation, Mangiferin, anti-bacterial and anti-viral effects. At present, mango cough tablet, mango cough capsule, honeysuckle mango capsule, honeysuckle mango tablet preparations have been on the market in China, and mango leaf extract has mangiferin as its active ingredient.

Oral administration of mangiferin reduced the blood glucose level of Kk-AY mice Beet Root Powder, but had no effect on the blood glucose level of normal mice, suggesting that mangiferin can be used in the treatment of non-insulin-dependent diabetes mellitus.

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Varieties of mango leaf extract

Mango fruit is kidney shaped, and the main varieties are native mango and exotic mango. Before ripening, the skin of native mango is green, while that of exotic Mangiferin is dark purple. When native mango is mature, the skin color is unchanged, while that of exotic Gardenia Yellow is orange or red. Mango flesh juicy, sweet taste, soil mango seeds large, fiber, foreign species without fiber.

An evergreen tree native to Capsicum Oleoresin having leathery leaves and alternate growth; warm, small flowers, yellow or reddish, terminal panicles, mango and poor light gray wood. Also used as having game names, and some nicknames. Mango fruit contains sugar, protein and crude fiber, and the precursor carotene of vitamin A in mango is very high, which is rare in all fruits. Secondly, the content of vitamin C is not low. Minerals, proteins, fats, sugars, etc. are also the main nutrients. Mango is one of the famous tropical fruits. Because of its delicate flesh and unique flavor, it is deeply loved by people, so it is known as the “king of tropical fruits”.

Efficacy: Nourishing Yin and kidney. For kidney deficiency. Invigorating stomach and eliminating food; resolving phlegm and Sweet Potato Powder. Main diet stagnation; anorexia; cough; hernia; orchitis.

Mango is a famous tropical fruit, known as the king of tropical fruits. Mango production is distributed in more than 100 countries in Asia, South America, North America, Africa and Oceania, with a cultivation area of more than 2 million hectares and an annual output of more than 16 million tons. China is one of the major mango producing countries. Mango production is distributed in Taiwan, Guangdong, Guangxi, Hainan, Fujian, Yunnan, Sichuan and other provinces. Mango, with its unique flavor and high vitamin content, has a certain position in the world production and trade.

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The function of mango leaf extract

Mango leaves are the leaves of Mangifera indica L. Acerola Cherry Extract is the most famous fruit in the East and one of the five tropical famous fruits. According to the collection of Materia Medica, mango “benefits the stomach, stops nausea and dizziness”, while mango leaf, as a traditional Chinese medicine, was recorded in the dictionary of traditional Chinese medicine in 1977. Mango leaves are sour, sweet, cool and even in nature. They have the functions of relieving asthma, Red Cabbage Color, expelling phlegm, immunity, anti inflammation, relieving pain, protecting liver and benefiting gall, anti lipid peroxidation, anti-virus, anti-tumor and anti-bacterial. Mango leaves mainly contain ascorbic acid, mangiferin, mangosteen, quercetin, kaempferol and other chemical components. There are few reports on the antitussive and expectorant effects of 3-Indolylcarbinol in China. In this experiment, mango leaves were used as raw materials to study the antitussive and expectorant effects of mango leaves extract, which provided a scientific basis for the development and utilization of mango leaves.

Mango leaves can make tea. The only thing to note is that mango is poisonous. If you have skin disease or Mangiferin, you should avoid eating. According to personal experience, even if there is no sensitive person, eating several mangoes at a time will make you lose your voice immediately.

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Sample preparation of mango leaf extract

Accurately weigh 400g Mangifera Indica Extract, add 8 times the amount of 70% ethanol solvent, soak for 1 hour, boil and reflux for 2 hours, filter while hot, add 8 times the amount of 70% ethanol solvent to the filter residue, continue to reflux for 2 hours, combine the filtrate for 2 times, put it at room temperature, accurately measure the volume of the extract solution to a total of 6.86l, and concentrate to 800ml according to the ratio of crude drug (Gardenia Yellow): solution volume (ML) = 1:2 , 3000 R / min, centrifugation for 15 min to discard the precipitate. Accurately measure 800ml of D101 macroporous adsorption resin pretreated, and wet column.

Take the sample of the treated concentrated solution, the Astaxanthin Supplier is 40min / BV, pre elute with 3bv water, elute with 5 times of 15% ethanol, recover ethanol from 15% ethanol eluent and concentrate to the end, weigh 10g of mangiferin crude product, heat and dissolve with 20ml of 50% ethanol solution to make the solution supersaturated, stand, cool and filter, scrape off the filter cake, wash the sediment with 20ml of 50% ethanol solution, mix well Evenly, filter again, put the filter cake into the vacuum drying oven for drying at 60 ℃, and obtain the Mango Leaf Extract sample.

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Preparation of mango leaf extract toothpaste

At present, the new health care products or drugs developed with Mango Leaf Extract as the main component are generally oral preparations. Because the bioavailability of mangiferin is very low, the clinical trial effect of these preparations is not ideal.

A. Glue making: according to the amount in the Gardenia Yellow, put glycerin, 70% sorbitol solution, xanthan gum and sodium carboxymethylcellulose into the glue making pot, stir at high speed for 7 minutes, then add water, xylitol, sodium pyrophosphate, potassium sorbate and citric acid, continue to stir until Ginkgo Biloba Extract is colloidal, stand for 6 hours, and then stir at high speed for 20 minutes to get transparent and uniform glue.

B. Kneading: pour the glue into the kneader, add other components in the formula, mix evenly, and get the sticky paste.

C. Grinding: put the paste into the colloid mill and grind until Red Beet Root Powder becomes a uniform and soft paste.

D. Aging: transfer the ground paste into a temporary storage tank, and allow it to stand for 12 hours, so that the bubbles in the paste will be discharged, and the paste will become more viscous and uniform.

E. Vacuum degassing: pour the aged paste into the vacuum degasser, and turn on the machine to remove the bubbles in the paste.

F. Filling: put the vacuum degassed paste into the automatic filling machine, separately put it into the toothpaste tube, and then seal the tail to get the product mango leaf extract toothpaste.

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Preparation of toothpaste with mango leaf extract

  1. Formula:
  2. Mango Leaf Extract 20g, salicylic acid 4G, dicalcium phosphate 500g, sodium pyrophosphate 17g, glycerin 350g, 70% sorbitol solution 160g, xanthan gum 3G, sodium carboxymethylcellulose 4G, xylitol 20g, potassium sorbate 2G, citric acid 10g, menthol 10g, sodium dodecyl sulfate 30g, water 100g.
  3. Production method: including the following steps(Mangifera Indica Extract):
  4. Glue making: according to the amount in the Mangiferin, put glycerin, 70% sorbitol solution, xanthan gum and sodium carboxymethylcellulose into the glue making pot, stir at high speed for 7 minutes, then add water, xylitol, sodium pyrophosphate, potassium sorbate and citric acid, continue to stir until it is colloidal, stand for 6 hours, and then stir at high speed for 20 minutes to get transparent and uniform glue(Flax Seed Extract).
  5. Kneading: pour the glue into the kneader, add other components in the formula, mix evenly, and get the sticky paste.
  6. Grinding: put the paste into the colloid mill and grind until it becomes a uniform and soft Citrus Aurantium Extract.
  7. Aging: transfer the ground paste into the temporary storage tank, and allow it to stand for 12 hours, so that the bubbles in the paste will be discharged, and the paste will become more viscous and uniform.
  8. Vacuum degassing: pour the aged paste into the vacuum degasser, and turn on the machine to remove the bubbles in the paste.
  9. Filling: put the vacuum degassed paste into the automatic filling machine, separately put it into the toothpaste tube, and then seal the tail to get the product mango leaf extract toothpaste.
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